Thermodynamic stabilities are not the sole determinant of the conformational distributions of cellular RNAs especially during transcription. This project focuses on conformational search and capture probability model of ‘simple’ tertiary RNA folding, the impacts of transcription using the same RNA and still simpler, more pliable model RNAs that can be used to systematically dissect features and factors important in co-transcriptional folding.

Goal: 

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