Using this reconstitution hypothesis, we propose to predict, in a “bottom-up” manner, the folding behavior of natural RNAs and RNA-protein complexes. The results will significantly advance our understanding, either providing strong evidence for the reconstitution hypothesis and demonstrating predictive power via multiple non-trivial tests, or identifying complexities in RNA and RNA/protein behavior that can be tested and incorporated into next-generation models.

Goal: 

Using this reconstitution hypothesis, we propose to predict, in a “bottom-up” manner, the folding behavior of natural RNAs and RNA-protein complexes. The results will significantly advance our understanding, either providing strong evidence for the reconstitution hypothesis and demonstrating predictive power via multiple non-trivial tests, or identifying complexities in RNA and RNA/protein behavior that can be tested and incorporated into next-generation models.